Natural Nootropics – The 21 Top Smart Drugs For Your Brain in 2020!

If you want your brain to be fast and alert and you are looking for a natural or synthetic supplement for it, Nootropics is the solution to your problem.

Nootropic is natural or synthetic supplements that are a benefit to cognitive development in healthy people.

Natural nootropic supplements help to reach a peak of mental potential without any risks and keeping it more robust.

Many of these can boost memory, focus, creativity, alertness, and general cognitive functions. Nootropic may also reduce the decline in brain function due to age.

However, the definition of Nootropic has broadened over time to include any substance, pharmaceutical, or natural that may enhance brain functions without any risks or side effects.

Let’s dive in to learn further about these amazing components that can give you mighty power through improving your cognitive abilities.

Also Read: 10 New Tips to Boost Memory and Improve Brain Power [2020]


Nootropics are natural ingredients, which makes the brain work faster and much stronger. Even though it works for a limited period, but still, they are useful.

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Are you eating for your brain? Many brain healthy foods are rich in polyphenols and essential fats which improve endothelial function by protect our arteries from oxidative damage/inflammation. Several of these foods come from the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet published in 2015. Curcumin, the active constituent in turmeric, increases brain derived neurotrophic factor (BDNF), a neuro-protective protein that reduces the damaging effects of hypercortisolemia on the brain, increases neurogenisis (growth of new nerve cells), protects the brain against dementia, and improves mood. Lions mane is concentrated with nerve growth factor (NGF). NGF promotes synaptogenisis and the formation of new neurons. Coffee is widely known to confer neuroprotective benefits. There is a body of literature to suggest that coffee decreases the incidence of Parkinson and dementia, decreases incidence of depression, slows memory loss, and improves cognition. PMID: 28507563. Blueberries are a rich in antioxidants such as anthocyanins and resveratrol. In the literature, blueberries improve cardiovascular support, improve insulin sensitivity, enhance cognitive function (via increased NO production), and improve memory in the elderly. Cold water oily fish such as sardines, mackerel, and salmon are rich in EPA and DHA, long chain omega-3s found exclusively in marine organisms. DHA is probably the most important of the different types of omega-3s due to its important role in brain health. Walnuts (and pecans) boast the highest phytochemical and antioxidant capacity amongst tree nuts. These flavonoids are associated with improved blood lipid profiles, anti-atherogenic effects, and enhanced blood sugar control. Cacao is rich in flavonols which buffer ROS. Cacao is rich in magnesium, which promote vasodilation of blood vessels and can improve insulin resistance, cardiometabolic function, and cognitive function. PMID: 25344629. Coconut is made up of medium chain triglycerides (MCT), mostly caprylic and lauric acid. MCTs are metabolized differently than long chain fatty acids and are more rapidly oxidized for ketone utilization.

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Here are some of the ways a nootropic supplement can help to build a better brain:

  1. Increases circulation to the brain
  2. Provides essential brain nutrients
  3. It Provides missing nutrients in case you are a vegetarian
  4. Provides precursors to important neurotransmitters
  5. Increases energy, oxygen, and blood flow to the brain
  6. Reduces brain inflammation
  7. Protects the brain from toxins
  8. Minimizes effects of brain aging
  9. Aids in the formation of new brain cells
  10. Increases flexibility to stress

Nootropic pills, supplements, and other brain boosters deliver all of these benefits when consumed by a healthy adult. Some supplements have rapid effects, while others take time.

Nevertheless, in the end, they work and give a positive outcome.


There are plenty of natural substances that act as a nootropic.

They nourish and protect the brain- such as amino acids, vitamins, minerals, antioxidants, herbs, fatty acids, and much more.

However, everyone has a different way of leading life, so no nootropic supplements work equally for everyone.


21 natural nootropic supplements of 2020

There are many nootropics available, but some of them which are very effective and are best nootropic supplements are:

1) Acetyl-L-Carnitine

Acetyl-L-Carnitine (ALCAR) is a form of amino acid Carnitine. Amino acids are building blocks of protein and are very useful for a healthy brain.

Amino acids are present in protein-rich foods in the diet, but they are not enough from the diet alone. ALCAR works as a whole by creating acetylcholine. Acetylcholine is a neurotransmitter required for learning and memory functions.

It can improve mental clarity, alertness, mood, and memory.

ALCAR is also an antidepressant which gives relief to depression better than antidepressant drugs prescribed by the doctors.

2) Resveratrol

The most common smart drug which is available is Resveratrol.

Resveratrol is an antioxidant that is present in grapes, raspberries, and blueberries. It is also found in peanuts and chocolates.

Resveratrol plays a vital role in preventing the deterioration of an essential part of the brain connected with memory.

One of the clinical trials on a small group of healthy older adults took 200 mg of Resveratrol per day for 26 weeks and showed immense improvement in memory.

3) Creatine

Creatine is mainly an amino acid often used by bodybuilders and athletes to increase lean muscles and to enhance physical performance.

creatine supplements

A natural substance plays a vital role in energy metabolism. Other than this, Creatine is also a brain booster. It is mostly found in red meat.

One study on vegetarian and vegan found that Creatine supplements increase mental performance, intelligence, and processing speed.

Creatine carried supplements have a tendency to improve memory and thinking skills in people who do not eat meat.

This common smart drug has many owners. Still, the most popular is by a company named ON and is renowned by many other supplements.

4) Taurine

Another amino acid, Taurine, is usually used to increase physical performance.

Taurine is high in concentration in the brain as it lets in and out the movement of potassium, sodium, calcium, and magnesium from the brain cells.

Taurine also activates GABA receptors in the brain region to minimize anxiety, insomnia, and other signs of GABA deficiency.

5) Tryptophan

Tryptophan is potent for the formation of two cardinal brain chemicals; serotonin- a happy cell and melatonin- a hormone that regulates the sleep cycle.

6) Tyrosine

Tyrosine is a precursor of dopamine, the neurotransmitter that helps to keep focused and motivated. Feeling of fatigue, moody, and unable to concentrate means the level of dopamine is low.

It also plays a huge role in depression and addictions of all kinds. A low level of tyrosine shows a lack of focus.

Tyrosine supplementation is an excellent idea to use if you are suffering from stress, overworked, or not enough sleep.

7) Theanine

Theanine is one of the most unusual brain enhancers. It is active in green tea and black tea.

It helps to concentrate on the relaxed mind without causing drowsiness.

Theanine increases the level of the neurotransmitter serotonin, dopamine, and helps to improve mood, learning, and memory recall.

This is a great supplement for achieving a state of calm and focus.

8) Rhodiola Rosea

Rhodiola Rosea (Arctic Root) has high adaptogen properties. Like all adaptogens, it improves the ability to handle stress.

Rhodiola Rosea supplements

It increases the level of dopamine, serotonin, and norepinephrine.

This herb is also suitable for brain fog, trouble concentration, and low energy, along with stress and anxiety.

It also helps to improve mental processing by reducing fatigue.

9) Bacopa Monnieri

Bacopa Monnieri has been in use in ayurvedic medicines as a cognitive enhancer.

It is an excellent herb to improve memory, focus, and concentration while reducing stress. It works by balancing brain chemicals, as it reduces stress hormone cortisol.

This herb is also very effective for age-related mental decline. The effects of Bacopa are not rapid. It takes two to three months to experience maximum benefits.

Bacopa Monnieri also shows that it may cause diarrhea and an upset stomach. Nevertheless, these just mild side effects are not harmful.

10) Ginkgo Biloba

Ginkgo Biloba is one of the most popular herbal remedies in the world.

It is an excellent cognitive enhancer; in some countries, it is available only as a prescription medication.

It mainly works in increasing circulation to the brain, balancing brain chemicals, and protecting the brain from damage.

It is useful for poor concentration, memory loss, fatigue, mental confusion, depression, and anxiety.

Ginkgo Biloba has shown mixed effects. It is a blend not only as a cognitive enhancer but also reduces age-related mental decline.

One study has shown that middle-aged people who were on ginkgo Biloba, has improved thinking and memory skills.

11) Citoline

Citicoline can improve memory, concentration, focus, and attention.

Our body makes Citicoline from the choline present in foods such as eggs, beef, and seafood. Still, it won’t be enough, as we can’t eat an adequate amount to consume significant cognitive enhancement.

In some countries, Citicoline, by prescription, is allowing those who have age-related severe memory loss.

This supplement works tremendously well by increasing blood flow to the brain, and the capacity to grow new brain cells.

The most common smart drug that is available is Alpha GPC.

12) Curcumin

Curcumin is an extract of turmeric, as it is India’s natural healing system.

Curcumin supplements

It is an excellent antioxidant and a brain tonic that improves memory and concentration by increasing blood flow to the brain.

It has the tendency to boost levels of serotonin, dopamine, and brain-derived neurotrophic factor (BDNF), which is the protein that stimulates brain cell production.

13) Huperzine A

Huperzine A is the main compound extracted from Chinese moss (Huperzia Serrata).

Studies have shown that it enhances memory and learning in people in all stages of life.

It is a brain booster and works by increasing acetylcholine levels and stimulates new brain cell formation.

14) Lion’s Mane Mushroom

Lion’s Mane Mushroom is an odd-looking mushroom that has unique health benefits.

According to the legend, the Buddhist monks used this herb to stay focused during meditation.

Compounds in lion’s mane mushroom are not present elsewhere; they heal and protect nerve cells and stimulate the growth of new ones.

These compounds also help in treating a sleep disorder, cognitive and anxiety disorder, depression, and schizophrenia.

15) Phosphatidylserine

The Phosphatidylserine is present in higher concentrations in the brain cell membrane.

Phosphatidylserine is phospholipids. It means it acts as a gatekeeper of the brain, as it helps preserve the brain’s health.

It regulates the flow of nutrients in the brain and kicks out waste products while protecting them from toxins. Phosphatidylserine reduces stress while supporting memory, concentration, and learning. It mainly helps those who have ADHD and attention problems.

It is usually extracted from soy lecithin, but derived from sunflower lecithin is the more pure and highest quality of Phosphatidylserine.

The Phosphatidylserine supplements could improve thinking skills and memory. They could also help to fight age-related brain decline.

16) Vinpocetine

Vinpocetine is a new brain booster based on vincamine.

Vinpocetine supplements

It is a chemical found in the periwinkle plant. Vinpocetine is very famous in Europe and Japan, as it is superior to ginkgo Biloba as a brain booster.

It enhances brain functions, including blood flow to the brain, decreasing brain inflammation, and balancing neurotransmitter levels.

It is usually to treat brain fog, improved memory, and mental clarity, and protects the brain from aging.

17) Vitamin B12

Vitamin B12 has the most impact on the brain as compared with other vitamins.

Consuming B12 can make a strategic change in the health of the nervous system, brain function, and energy.

B12 is a blend in most of the nootropic formulas, brain supplements, energy drinks. 

It should be taken in an adequate amount, which means not too much and not too little.

To know the value of B12 in our body, there is a blood test of vitamin B12 to determine the level.

18) Vitamin D

Vitamin D has intense effects on the brain throughout our lives.

It can improve mood, memory, and problem-solving ability. The best source to manufacture Vitamin D in the body is sunlight.

However, unfortunately, in this modern world, people are too busy to sit in the sunlight and gain this opportunity.

If people who rarely go out or spend time outdoors, even use sunscreen for protection, they should consume vitamin D supplements.

Also, there are countries where sunlight is not sufficient due to climate change; those people must use vitamin D supplements as well.

Unlike vitamin B12, there are tests for Vitamin D to determine the level.

19) Magnesium

Magnesium is also named as a master mineral as it has over 600 biological functions.

Low consumption makes us tired and stressed. Eighty percent of Americans are low in this essential mineral.

Low level of magnesium not only makes tired but also, it makes us lose focus, leg cramps at night and sleeping problem.

Magnesium I-threonate is the new form of magnesium, which shows promising results in enhancing memory and other brain functions.

20) Omega 3 Fatty Acids

Omega-3 fatty acids may be the single supplement that is necessary for the brain.

Omega-3 Fatty Acids supplements

Omega-3 are present in cold-water fatty fish. DHA (Docosahexaenoic acid) is an omega-3, which is a primary structural component of the brain that regulates with language, creativity, memory, judgment, emotion, and attention.

DHA happens to play a vital role in maintaining the structure and function of the brain.

In fact, DHA accounts for around 25% of total fat and 90% of omega-3 found in brain cells.

DHA has also benefitted people who have shown a mild decline in brain functions. Good quality omega-3 supplement in the form of fish oil or krill oil.

Taking fish oil has shown to help reduce age-related decline in brain functions.

The best way to get the required amount of omega-3 fatty acids is by eating oily fish at least two portions per week. If not, then it is better to consume supplements that have benefits.

21) Multivitamin Mineral

A multivitamin-mineral supplement is popped to meet most of the brain’s essential nutrients.

Studies have shown that taken multivitamin supplements can alone improve memory and overall brain functions. It also protects from degenerative diseases.

It reduces symptoms of adult attention deficit hyperactivity disorder (ADHD).

These are some of the nootropic ingredients which make up a brain supplement to enhance focus, memory, and other cognitive abilities.

All these ingredients are safe and natural without any side effects.

Some supplements might cause mild side effects, but those are manageable to gain cognitive performance.

Age has certainly an inevitable effect on the abilities of our brain but it has been proven various times through most of the clinical trials that age related memory depletion is possible to avoid when you know what you really need to do.

These natural nootropics will not stop 100% aging process of brain. However, certainly, it can slow down it a bit for you, pal.


One of the most common smart drugs that are widely popular is Mind Lab Pro.

Mind Lab pro Review

This supplement has all-natural ingredients and is safe from any side effects.

This nootropic supplement has 11 elements, which are all-natural that work to improve memory, concentration, and mood.

There are many products in the market under the name of Nootropic. However, it is better to know them before buying them.

It is necessary to know the product before buying it. You should make a specific target which you want to achieve.

Having the desired goal can make you choose the right product and can have a better effect on the mind.

Many products have nootropic ingredients, but they are not very useful.

The ingredients used might be not of good quality or do not have any nootropic ingredients in it. Nevertheless, some supplements which have been selling online do have some nootropic ingredients in them, which can be effective readily.

For some, it will take time because of different body structures.

Also See: Biogen Introduced Drug to Slow Down Alzheimer Progression, Report Says!


Still, brain supplements have been in use all over the world.

They have shown effective results for those who need to gain memory focus and develop cognitive functions. Slight side effects have seen, but there are no significant symptoms that may have caused any damage or other problems.

People who want to use brain supplements as part of their lives. It is a good decision, but make sure you do your homework before buying any brain supplement products from the market.

Nootropic is the solution to those people who want to enhance their cognitive abilities which include, focus, and memory, and concentration, interest in work, and brain development.

Nootropic is a natural substance and is available online and in different stores.

These brain supplements have changed people’s lives by showing positive effects on their personal and professional lives.

They have made a significant change in them both physically and mentally.

It is easy to be in use by both adults and adolescents, is safe, and made from natural ingredients. Older people need these supplements more because of age-related mental decline.

It can be taken by adolescents as well who have their career at stake, to open their mind and decide what they want for their future.